Structure of the ATP-dependent oligomerization domain of N-ethylmaleimide sensitive factor complexed with ATP (2024)

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Structure of the ATP-dependent oligomerization domain of N-ethylmaleimide sensitive factor complexed with ATP (2024)

FAQs

What is the N Ethylmaleimide sensitive factor? ›

N-Ethylmaleimide-Sensitive Factor (NSF) is an essential component involved in the fusion of cellular membranes, particularly in the direct insertion, stabilization, and trafficking of GluA2 receptors at synaptic sites in the brain.

What is the structure of the ATP synthesis complex? ›

ATP Synthase - Structure

The structure of ATP synthase is very interesting. Inside the mitochondria there are different layers, and the ATP synthase is found within the layer known as the inner mitochondrial membrane. The enzyme actually goes through the inner membrane. ATP synthase has two major components: F1 and F0.

What is the function of the NRAS protein? ›

Normal Function

The NRAS gene provides instructions for making a protein called N-Ras that is involved primarily in regulating cell division. Through a process known as signal transduction, the protein relays signals from outside the cell to the cell's nucleus.

What is the function of N-ethylmaleimide? ›

N-ethylmaleimide (NEM) is an alkylating reagent that reacts with sulfhydryls and is commonly used to prevent disulfide bond formation in proteins [78].

What are the 3 structures of ATP? ›

The structure of ATP is a nucleoside triphosphate, consisting of a nitrogenous base (adenine), a ribose sugar, and three serially bonded phosphate groups.

What is the ATP producing structure? ›

Most of the ATP in cells is produced by the enzyme ATP synthase, which converts ADP and phosphate to ATP. ATP synthase is located in the membrane of cellular structures called mitochondria; in plant cells, the enzyme also is found in chloroplasts.

What is the complex that makes ATP called? ›

Human mitochondrial (mt) ATP synthase, or complex V consists of two functional domains: F1, situated in the mitochondrial matrix, and Fo, located in the inner mitochondrial membrane. Complex V uses the energy created by the proton electrochemical gradient to phosphorylate ADP to ATP.

What is the N factor? ›

“n-factor is defined as the number of moles of electron exchanged (lost or gained ) by one mole of salt.” For acid, the n-factor is described as the number of ions replaced for one mole of an acid in a reaction. Acids are species that give ions when dissolved in a solvent.

What is the NF E2 related factor? ›

Nuclear factor erythroid 2 (NF-E2)-related factor 2 (Nrf2) is a transcription factor that can regulate downstream target gene expression. Kelch-like ECH-associated protein 1 (Keap1) negatively regulates Nrf2 activation and translocation to target its 26S proteasomal degradation.

What are soluble n ethylmaleimide sensitive factor attachment protein receptors? ›

Soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs) are central components of a conserved protein machinery that governs most types of intracellular membrane traffic by virtue of their ability to form tight SNARE complexes that bring two membranes together.

What is the function of NSF protein? ›

Initially, due to its ATPase activity, NSF was thought to be the motor that drove membrane fusion. Subsequent studies have shown that NSF actually plays the role of a chaperone by activating SNAP receptor proteins (SNAREs) so that they can participate in membrane fusion.

References

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